Diabetes mellitus is a chronic, metabolic disorder characterized by elevated blood glucose levels, which leads to a major cause of blindness, kidney failure, heart attacks, and stroke. According to WHO, the number of people with diabetes has been raised from 108 million in 1980 to 422 million in 2014. An estimated stated that, in the year 2016, 1.6 million deaths were directly caused by diabetes. Diabetes prevalence has been rising more rapidly in middle and low-income countries. In Indian traditional medical system Ayurveda, several herbal formulations used for treatment of diabetes. In the current study, Curcuma longa (CL) and Trigonella foenum graecum (TFG) plants used to treat the alloxan induced diabetic rats. The rats divided into six groups and named as group-I (Normal), group-II (Diabetes), group-III (Diabetes + CL), group-IV (Diabetes + TFG), group-V (Diabetes + CL + TFG) and Group-VI (Glibenclamide). CL and TFG extracts individually and in combination were administrated orally at a concentration of 250mg/kg BW to group-III, group-IV and group-V for 30 days. After experimental period rats sacrificed and liver tissue of all the groups were isolated for histopathological studies and hematoxylin and eosin stain used. The histopathological observations of group-I shows the normal cyto-architecture, whereas, several degenerative changes observed in group-II and it shows, periportal necrosis of hepatocytes and congested portal vessels as well as areas of inflammatory cell infiltration. This condition was also reversed in rats treated with CL, TFG and CL+TFG plant extracts and glibenclamide treated rats. These histopathological results confirm the anti-diabetic potential of CL and TFG.