Okra is one of the important vegetables with high export potential and valued for its green fruits, rich in proteins, calcium, phosphorus, iron, carotene and vitamins. Analytical method was developed to know the residues of acetamiprid, imidacloprid, thiamethoxam in okra using LC-MS/MS. The LOD ranges from 0.002-0.008 µg g-1 for acetamiprid and thiamethoxam, imidacloprid. Field trial on residue and dissipation kinetics of neonicotinoide in okra at single and double dose revealed the initial deposits of acetamiprid, imidacloprid and thiamethoxam were 2.03, 1.13 and 1.54 mg kg-1 with half-life of 3.06, 2.38 and 3.38 days at single dose and the initial deposition of 4.04, 2.26 and 3.16 mg kg-1 with half-life of 3.09, 3.36 and 4.05 days at double dose, respectively. Dipping of okra fruits in salt solution and boiling (T10) reduce 89.82 and 73.66 per cent of acetamiprid and imidacloprid. Similarly dipping in 4 % acetic acid (T5) reduces 66.63 per cent of thiamethoxam in okra. The safety evaluation recorded that the, hazard index value were less than 1 for children and adult upon consumption of okra fruits harvested from the residue and dissipation experiment at 5 days after application.